5/3/2023 0 Comments Cetirizine synthesis pdf![]() Thus far, the vast majority of approaches to this problem have involved the coupling of alkyl halides (or related species) to organometallic reagents ( 15– 18). Historically, alkyl-alkyl transition metal–catalyzed cross-coupling reactions have been difficult to accomplish, but examples can be traced to the early work of Kharasch in the 1950s ( 4), followed by Noller ( 5, 6) and Kochi and Tamura ( 7, 8) in the 1960s to more recent work from the groups of Suzuki ( 9), Fu ( 10), Knochel ( 11), Kambe ( 12), Oshima ( 13), and many others ( 14). Indeed, such transformations have been on organic chemists’ wish list for well over a century ( 2, 3). Similarly, a general and practical approach to C(sp 3)–C(sp 3) variants would have the potential to open up new vistas in retrosynthetic analysis. ![]() For example, pioneering work on the cross-coupling of halogenated aromatic or vinylic (sp 2) systems (Heck, Suzuki, Negishi, and Stille) has transformed the practice of organic synthesis ( 1). The heart of chemical synthesis relies on forging new C–C bonds, with the evolution and advancement of the field being easily correlated to new developments on this front. ![]()
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